Also see https://www.mediawiki.org/wiki/Manual:MediaWiki_architecture#Caching
which has this: "The last caching layer consists of the PHP opcode cache, commonly enabled to speed up PHP applications. Compilation can be a lengthy process; to avoid compiling PHP scripts into opcode every time they're invoked, a PHP accelerator can be used to store the compiled opcode and execute it directly without compilation. MediaWiki will "just work" with many accelerators such as APC, PHP accelerator and eAccelerator.
Because of its Wikimedia bias, MediaWiki is optimized for this complete, multi-layer, distributed caching infrastructure. Nonetheless, it also natively supports alternate setups for smaller sites. For example, it offers an optional simplistic file caching system that stores the output of fully rendered pages, like Squid does. Also, MediaWiki's abstract object caching layer lets it store the cached objects in several places, including the file system, the database, or the opcode cache.
So does Zend_OPcache_v7.0.3-dev_35188 just work?
Fred