It has long been the case that the load.php entry point, to support more aggressive caching, should not depend on details of the current session. For example, it should not access the session user, and should use its own 'lang' parameter for i18n messages rather than the session user's language.
After a fair bit of work[1] by Gergő Tisza, Timo Tijhof, Bryan Davis, and myself, we have now flipped the switch to make attempted session access fail with an exception when serving load.php. This will go out to Wikimedia wikis with 1.28.0-wmf.1 next week.[2]
We've had this in logging mode for a while and haven't seen any log messages in production recently, so we anticipate that this change won't cause any issues for Wikimedia wikis. Third-party wikis may have to update their extensions.
If there are problems, they'll manifest as missing CSS or JavaScript in the page, and when examining the load.php output there will be a comment at the top reporting that a BadMethodCallException was caught. The logged exception's message will be "Sessions are disabled for this entry point".
[1]: See https://phabricator.wikimedia.org/T127233 and its subtasks. [2]: See https://www.mediawiki.org/wiki/MediaWiki_1.28/Roadmap for the schedule.