The first question I have is: how much trouble will we encounter if we're not using wiki markup? We store everything as HTML5 everywhere, and we're converting our old sites to HTML5 on import.
Our current parser pipeline also converts the mixed wiki/html markup into an annotated HTML5 DOM, and then (actually since today) converts that to WikiDom. So good support for back-and-forth between WikiDom and HTML DOM is highly likely.
Gabriel