Concerning the complicated paragraph in [[Paracetamol]], I can name many areas of Wikipedia where the science becomes so dense that the layman will admit it sounds really good but fails to come any closer to understanding the exact issues. Many mathematical articles stop making sense at some point, and I admit that not every medical article is an exemplar of lay-oriented clarity.
When initially starting WikiProject Clinical Medicine, we struggled with this question. The decision was to escalate the level of difficulty, so all relevant information would be covered. The lay reader would have to drop it at some point, and none of the participants saw a great deal wrong with this.
This is not to say the paragraph in question cannot be improved upon.
JFW