[WikiEN-l] The sharpest criticism of a protein-only or genetics hypothesis regarding [[prion]]

[Jay Litwyn]

Someone objected to the new section on jenetiks being stricken with the 
conclusion that genetics is the cause. I moved to strike it, because it was 
confusing. In other words, it does not make the conclusion that genetics is 
the cause, nor does it support anything it does say, so I would delete the 
section to over-rule an objection.

I was looking for a citation, because a magazine or something does not 
archive editorials. It turns out that Gajdusek did not like it when 
Prussiner introduced the word "prion" into English. If I had been looking 
for "Scrapie", then I might hav found it. It belongs in a subsection in the 
section about debate. If Prussiner can be credited with anything other than 
a Nobel prize, it is that his hypothesis tested the dominant theory that 
life requires both D.N.A. and protein to reproduce.

In a sympathetic jesture, jenetiks does hav things to say about Protease 
Resistant Protein, so I would give genetics the last word in the debate.

"Agent of [[:category:amyloidosis]] survives temperatures that destroy 
protein and [[DNA]]"
<ref name="pmid10716712">{{cite journal
|author=Brown P, Rau EH, Johnson BK, Bacote AE, Gibbs CJ, Gajdusek DC
|title=New studies on the heat resistance of hamster-adapted scrapie agent: 
threshold survival after ashing at 600 degrees C suggests an inorganic 
template of replication
|journal=[[Proc. Natl. Acad. Sci. U.S.A.]]
|volume=97
|issue=7
|pages=3418-21
|year=2000
|month=March
|pmid=10716712
|pmc=16254
|doi=10.1073/pnas.050566797
|url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10716712
|issn=
}}</ref>