Two or more different epitopes or antigens can be recognized simultaneously by bispecific antibodies owing to their distinct structural characteristics which are engineered through various techniques. The binding affinities of these antibodies are important parameters that mediate their efficacies and suitability in many diseases such as cancer, autoimmune diseases and various others. Creative Biolabs has great pleasure to inform our customers that we provide a complete Ms service, which encompasses the bispecific antibody design, engineering, production and analysis. With the most advanced technology platforms, Creative Biolabs is in a position to assist buyers to evaluate and develop the Bs4ABs further in the direction of their therapeutic use. For more: https://www.creative-biolabs.com/bsab
Key Concepts Related to Bispecific Antibody Binding Affinity:
Definition:
Binding affinity is the measure of the strength with which an antibody binds to its target antigen. It can be measured in a number of ways, one of them being the use of the dissociation constant Kd. Lower values of Kd are taken to imply higher affinity.
Importance of Binding Affinity:
Efficacy: Targeting efficacy can be improved for bispecific antibodies through use of higher binding affinity since this ensures tighter and more stable interaction with most targets of the antibodies.
Specificity: Having increased affinity toward a specific target may grant reduced off-target effects, hence enhancing the safety of this type of therapy.