It's not "supported", but I see no reason why it couldn't work.
You'd
probably want to do it from the ResourceLoaderRegisterModules hook (which
is fired after core modules are registered). Also, $moduleInfos is
protected (because you're not supposed to modify it :D), so you'd have to
cheat with some reflection to access it probably.
But perhaps there's a simpler way? What are you trying to do? The simplest
thing would be to just create your module, give it 'position'=>'top' to
make it execute before almost all other modules load, and add it on all
pages from some hook.
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Bartosz Dziewoński