Article: https://medium.com/@paul_irish/debugging-node-js-nightlies-with-chrome-devtools-7c4a1b95ae27

tl;dr: In Node nightly (and Node 7, once it's released), `node --inspect server.js` will enable interaction with Chrome's devtools for debugging, profiling, heap snapshotting etc. Currently, this requires https://github.com/node-inspector/node-inspector.

Gabriel